

The Kel-Tec obviously has plenty of accuracy for a self-defense application at close range (even at 50 feet the shots were well within the 'vital' zone), for those who may for various reasons not be able to use a better 'stopper'. Whatever feeds most reliably in a particular firearm would be reasonable and best; for this particular Kel-Tec feeding seems not to be an issue so far, so if the 'Supreme' rounds (or any of the others) fed reliably 500 in a row or so, it would be my choice.
The Single-Six obviously shows more potential for a hunting application, at least when both guns are fired with factory sights. I also LIKE it more due to the 'classic' sixgun appearance and handling. Oddly enough, it seems less noisy, despite the somewhat generous cylinder-gap.
If I could have only one of them for MY situation (.44 Spl for CCW, scoped .22 LR & Hornet Contender barrels if I want to be 'serious' hunting with a handgun, so just want a 'woods walking' or 'chore' gun for the occasional varmint or whatever, or just to plink), I'd take the Single Six. If I lived in an urban area, needed a CCW gun in .22 Mag due to handicap or inability to shoot a heavier gun, I'd be ok with the Kel-Tec.